Adenosine receptors in GtoPdb v.2023.1

Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [112]) are activated endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for antagonist-bound [155, 316, 224, 62], agonist-bound [379, 205, 206] and G protein-bound A2A [49] have been described. The of an A1 receptor [130] adenosine-bound receptor-Gi complex [87] resolved cryo-electronmicroscopy. Another structure obtained with X-ray crystallography has reported [58]. A2B elucidated [57]. caffeine is a nonselective antagonist receptors, while istradefylline, selective antagonist, market treatment Parkinson's disease.